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Furthermore, while we did not observe interactions between ENL and 1 M CRBN, we cannot rule out the possibility that they interact at concentrations higher than those we were able to assess
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However, there is great variation on the impact of changing specific thresholds will have by region dependent on the historical vaccination coverage, current age structure, and HBV genotype
The half-life difference between the two forms is roughly 8 days versus minutes, so the dosing frequency mismatch is dramatic